Research groups and research areas involved in MOBI4Health
LABORATORY OF PROTEIN BIOCHEMISTRY: Head – Prof. dr hab. Krzysztof Liberek
Research areas:
- Chaperone proteins
- Heat shock response
- Mechanism of action of Hsp100 chaperones
- Small heat shock proteins
- Hsp70 and Hsp40 chaperones
LABORATORY OF BIOPHYSICS: Head – Dr hab. Jacek Piosik
Research areas:
- Stacking interactions between aromatic compounds
- Interactions of ligands with DNA
- Hetero-complexation of biologically active aromatic compounds
- Mathematical models for hetero-complexes analyses
- Mechanisms of mutagens and toxins action
- Modulation of biological activity of ligands
LABORATORY OF PHYSICAL BIOCHEMISTRY: Head – Prof. UG dr hab. Bogdan Banecki
Research areas:
- Functions of MTHFR and CBS genes during formation of homocysteine in the context of therapeutic and preventive aspects in patients with ischemic brain stroke
- Effects of using silicone implants by determining the influence of linear and cyclic polysiloxanes on stability and structure of proteins
- Practical applications of chromatographic methods of quality control and analytical method validation
- Methods of isolation and testing of new compounds with potential pharmaceutical application
- Biophysical analysis of protein structure and function
LABORATORY OF EVOLUTIONARY BIOCHEMISTRY: Head – Prof. dr hab. Jarosław Marszałek
Research areas:
- Molecular mechanisms of iron-sulfur cluster biogenesis
- The role of the Hsp70 machinery in mitochondrial iron-sulfur cluster biogenesis and maintenance and propagation of mitochondrial genome
- Molecular evolution of the Hsp70 systems
- Molecular and biochemical evolution of proteins
LABORATORY OF MOLECULAR BIOLOGY: Head – Prof. dr hab. Igor Konieczny
Research areas:
- Multi-molecule complexes formed on DNA by replication proteins, their structural bases, functions and dynamics
- Molecular mechanism of protease activity on substrates bound to DNA
- The function of plasmid encoded post segregational killing system in the context of its components interactions with DNA and their stability
- Experimental approaches, including in vivo tests, in vitro reconstituted assays, real-time kinetic experiments or single-molecule analysis for the analysis of activities conducted on DNA in bacteria
LABORATORY OF PLANT PROTECTION AND BIOTECHNOLOGY: Head – Prof. dr hab. Ewa Łojkowska
Research areas:
- Molecular markers for detection, identification and differentiation of plant pathogenic bacteria from different resources
- Identification of factors determining virulence of plant pathogenic bacteria
- Naphtoquinons – plant secondary metabolites with anticancer activity
- Arabidopsis thaliana as a model organism for identification of genes determining enzymes involved in the biosynthesis of coumarins
- Molecular markers for identification and study the diversity of Cyanobacteria
- Conservation of Polish orchids by micropropagation, cryopreservation and biobanking of seeds and tissues
LABORATORY OF MOLECULAR DIAGNOSTICS: Head – Prof. dr hab. Krzysztof P. Bielawski
Research areas:
- Molecular diagnostics of liver diseases
- Study of hbv drug resistance
- Photodynamic inactivation of multidrug resistant microorganisms
- Photodynamic therpy of cancer
- The study of a new photosensitizers
- Therapeutic potential of activation of p53 family members to treat cancer
LABORATORY OF PLANT BIOCHEMISTRY: Head – Prof. dr hab. Antoni Banaś
Research areas:
- Enzymes connected with wax esters biosynthesis
- Lipid catabolism during seeds germination
- Physiological role of lysophospholipid: acyl-CoA acyltransferases
- Enzymes connecting with triacylglycerols biosynthesis
- Lipids of roots and leaves
LABORATORY OF BIOLOGICAL PLANT PROTECTION: Head – Prof. UG, dr hab. Sylwia Jafra
Research areas:
- Biological control of plant pathogens
- Antibacterial activity of Pseudomonas spp.
- Quorum sensing of gram-negative bacteria
- Quorum quenching as a strategy for biocontrol of plant pathogens
LABORATORY OF BIOLOGICALLY ACTIVE COMPOUNDS: Head – Prof. UG, dr hab. Inż. Aleksandra Królicka
Research areas:
- Analysis of biologically active plant secondary metabolites and other compounds (synthetic peptides, nanoparticles) which possess antimicrobial and antifungal activities
- Plant transformation
- Aeroponic cultures
- Extraction of secondary metabolites from plant tissues
LABORATORY OF VIRUS MOLECULAR BIOLOGY: Head – Prof. dr hab. Krystyna Bieńkowska-Szewczyk
Research areas:
- Structure and functions of herpesvirus proteins
- Mechanisms of viral cell-to-cell spread
- Viral immune evasion strategies
- Structure and functions of Hepatitis C virus (HCV) envelope glycoproteins
- Construction of viral vectors for research and vaccine applications
- Production of recombinant viral proteins
LABORATORY OF RECOMBINANT VACCINES: Head – Prof. dr hab. Bogusław Szewczyk
Research areas:
- Construction of recombinant vaccine against influenza virus
- Construction of recombinant vaccine against Newcastle virus
- Construction of recombinant vaccine against rabbit hemorrhaging disease virus
- New diagnostic tests for detection of influenza viruses
- Baculoviruses as biopesticides and vectors for gene expression
LABORATORY OF BIOPOLYMERS STRUCUTRE: Head – Prof. UG, dr hab. Stanisław Ołdziej
Research areas:
- Temperature influence on structure and biological activity of small proteins and peptides
- Development of coarse-grained force-field unres and its application to study biochemical processes
- Experimental and theoretical study on mechanism of protein folding
- Theoretical studies on role of the myoglobin in unsaturated fatty acids metabolism
- Experimental and theoretical studies on transition metal ion complexes formed by biologically active peptides
LABORATORY OF BIOMOLECULAR SYSTEMS SIMULATIONS: Head – Prof. UG, dr hab. Rajmund Kaźmierkiewicz
Research areas:
- Theoretical modeling of interactions of the TraR protein and autoinducer molecules involved in quorum sensing mechanism
- Molecular dynamics simulations of NF-κB – DNA complexes
- Torsional angle dynamics simulations
- Molecular dynamics simulations of complexes of fatty acyl-CoA reductase (FAR) with the fatty acids
- Theoretical modeling of protein-ligand complex formation and ligand escape path simulations from an active site
- Prediction of the DNA quadruplex folding pathway and an evaluation of DNA quadruplex stability in an aqueous solution
- Prediction of the ligand binding site and the protein-ligand complex configuration using the global docking strategy
LABORATORY OF MOLECULAR BACTERIOLOGY: Head – Prof. GUMed, dr hab. Michał Obuchowski
Research areas:
- Molecular biology of Bacillus subtilis
- Protein phosphorylation in Bacillus subtilis
- Bacterial spore properties
- Oral vaccine based on spores
- Spore as carrier for enzymes
LABORATORY OF CELL BIOLOGY: Head – Prof. dr hab. Jacek Bigda
Research areas:
- Biology of breast cancer
- Prognostic and predictive markers of cancer
- Adenosine metabolism in cancer progression
- Regulation of apoptosis
- Mechanism of metastatic process
LABORATORY OF MOLECULAR ENZYMOLOGY: Head – Prof. dr hab. Andrzej C. Składanowski
Research areas:
- Biochemistry of cancer cell
- Skin damage by UVR and protective measures
- Adhesion receptors
- Growth factors receptors
- Cell migration
- Cell signaling