Research groups and research areas involved in MOBI4Health

LABORATORY OF PROTEIN BIOCHEMISTRY:  Head – Prof. dr hab. Krzysztof Liberek

Research areas:

  • Chaperone proteins
  • Heat shock response
  • Mechanism of action of Hsp100 chaperones
  • Small heat shock proteins
  • Hsp70 and Hsp40 chaperones

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LABORATORY OF BIOPHYSICS: Head – Dr hab. Jacek Piosik

Research areas:

  •     Stacking interactions between aromatic compounds
  •     Interactions of ligands with DNA
  •     Hetero-complexation of biologically active aromatic compounds
  •     Mathematical models for hetero-complexes analyses
  •     Mechanisms of mutagens and toxins action
  •     Modulation of biological activity of ligands

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LABORATORY OF PHYSICAL BIOCHEMISTRY: Head – Prof. UG dr hab. Bogdan Banecki

Research areas:

  • Functions of MTHFR and CBS genes during formation of homocysteine in the context of therapeutic and preventive aspects in patients with ischemic brain stroke
  • Effects of using silicone implants by determining the influence of linear and cyclic polysiloxanes on stability and structure of proteins
  • Practical applications of chromatographic methods of quality control and analytical method validation
  • Methods of isolation and testing of new compounds with potential pharmaceutical application
  • Biophysical analysis of protein structure and function

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LABORATORY OF EVOLUTIONARY BIOCHEMISTRY: Head – Prof. dr hab. Jarosław Marszałek

Research areas:

  • Molecular mechanisms of iron-sulfur cluster biogenesis
  • The role of the Hsp70 machinery in mitochondrial iron-sulfur cluster biogenesis and maintenance and propagation of mitochondrial genome
  • Molecular evolution of the Hsp70 systems
  • Molecular and biochemical evolution of proteins

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LABORATORY OF MOLECULAR BIOLOGY: Head – Prof. dr hab. Igor Konieczny

Research areas:

  • Multi-molecule complexes formed on DNA by replication proteins, their structural bases, functions and dynamics
  • Molecular mechanism of protease activity on substrates bound to DNA
  • The function of plasmid encoded post segregational killing system in the context of its components interactions with DNA and their stability
  • Experimental approaches, including in vivo tests, in vitro reconstituted assays, real-time kinetic experiments or single-molecule analysis for the analysis of activities conducted on DNA in bacteria

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LABORATORY OF PLANT PROTECTION AND BIOTECHNOLOGY: Head – Prof. dr hab. Ewa Łojkowska

Research areas:

  • Molecular markers for detection, identification and differentiation of plant pathogenic bacteria from different resources
  • Identification of factors determining virulence of plant pathogenic bacteria
  • Naphtoquinons – plant secondary metabolites with anticancer activity
  • Arabidopsis thaliana as a model organism for identification of genes determining enzymes involved in the biosynthesis of coumarins
  • Molecular markers for identification and study the diversity of Cyanobacteria
  • Conservation of Polish orchids by micropropagation, cryopreservation and biobanking of seeds and tissues

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LABORATORY OF MOLECULAR DIAGNOSTICS: Head – Prof. dr hab. Krzysztof P. Bielawski

Research areas:

  • Molecular diagnostics of liver diseases
  • Study of hbv drug resistance
  • Photodynamic inactivation of multidrug resistant microorganisms
  • Photodynamic therpy of cancer
  • The study of a new photosensitizers
  • Therapeutic potential of activation of p53 family members to treat cancer

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LABORATORY OF PLANT BIOCHEMISTRY: Head – Prof. dr hab. Antoni Banaś

Research areas:

  • Enzymes connected with wax esters biosynthesis
  • Lipid catabolism during seeds germination
  • Physiological role of lysophospholipid: acyl-CoA acyltransferases
  • Enzymes connecting with triacylglycerols biosynthesis
  • Lipids of roots and leaves

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LABORATORY OF BIOLOGICAL PLANT PROTECTION: Head – Prof. UG, dr hab. Sylwia Jafra

Research areas:

  • Biological control of plant pathogens
  • Antibacterial activity of Pseudomonas spp.
  • Quorum sensing of gram-negative bacteria
  • Quorum quenching as a strategy for biocontrol of plant pathogens

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LABORATORY OF BIOLOGICALLY ACTIVE COMPOUNDS: Head – Prof. UG, dr hab. Inż. Aleksandra Królicka

Research areas:

  • Analysis of biologically active plant secondary metabolites and other compounds (synthetic peptides, nanoparticles) which possess antimicrobial and antifungal activities
  • Plant transformation
  • Aeroponic cultures
  • Extraction of secondary metabolites from plant tissues

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LABORATORY OF VIRUS MOLECULAR BIOLOGY: Head – Prof. dr hab. Krystyna Bieńkowska-Szewczyk

Research areas:

  • Structure and functions of herpesvirus proteins
  • Mechanisms of viral cell-to-cell spread
  • Viral immune evasion strategies
  • Structure and functions of Hepatitis C virus (HCV) envelope glycoproteins
  • Construction of viral vectors for research and vaccine applications
  • Production of recombinant viral proteins

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LABORATORY OF RECOMBINANT VACCINES: Head – Prof. dr hab. Bogusław Szewczyk

Research areas:

  • Construction of recombinant vaccine against influenza virus
  • Construction of recombinant vaccine against Newcastle virus
  • Construction of recombinant vaccine against rabbit hemorrhaging disease virus
  • New diagnostic tests for detection of influenza viruses
  • Baculoviruses as biopesticides and vectors for gene expression

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LABORATORY OF BIOPOLYMERS STRUCUTRE: Head – Prof. UG, dr hab. Stanisław Ołdziej

Research areas:

  • Temperature influence on structure and biological activity of small proteins and peptides
  • Development of coarse-grained force-field unres and its application to study biochemical processes
  • Experimental and theoretical study on mechanism of protein folding
  • Theoretical studies on role of the myoglobin in unsaturated fatty acids metabolism
  • Experimental and theoretical studies on transition metal ion complexes formed by biologically active peptides

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LABORATORY OF BIOMOLECULAR SYSTEMS SIMULATIONS: Head – Prof. UG, dr hab. Rajmund Kaźmierkiewicz

Research areas:

  • Theoretical modeling of interactions of the TraR protein and autoinducer molecules involved in quorum sensing mechanism
  • Molecular dynamics simulations of NF-κB – DNA complexes
  • Torsional angle dynamics simulations
  • Molecular dynamics simulations of complexes of fatty acyl-CoA reductase (FAR) with the fatty acids
  • Theoretical modeling of protein-ligand complex formation and ligand escape path simulations from an active site
  • Prediction of the DNA quadruplex folding pathway and an evaluation of DNA quadruplex stability in an aqueous solution
  • Prediction of the ligand binding site and the protein-ligand complex configuration using the global docking strategy

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LABORATORY OF MOLECULAR BACTERIOLOGY: Head – Prof. GUMed, dr hab. Michał Obuchowski

Research areas:

  • Molecular biology of Bacillus subtilis
  • Protein phosphorylation in Bacillus subtilis
  • Bacterial spore properties
  • Oral vaccine based on spores
  • Spore as carrier for enzymes

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LABORATORY OF CELL BIOLOGY: Head – Prof. dr hab. Jacek Bigda

Research areas:

  • Biology of breast cancer
  • Prognostic and predictive markers of cancer
  • Adenosine metabolism in cancer progression
  • Regulation of apoptosis
  • Mechanism of metastatic process

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LABORATORY OF MOLECULAR ENZYMOLOGY: Head – Prof. dr hab. Andrzej C. Składanowski

Research areas:

  • Biochemistry of cancer cell
  • Skin damage by UVR and protective measures
  • Adhesion receptors
  • Growth factors receptors
  • Cell migration
  • Cell signaling

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